Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Clinic for Hospital Dentistry, Borås Hospital, Public Dental Health, Region Västra Götaland, Borås, Sweden.
Oral Dis. 2017 Sep;23(6):757-762. doi: 10.1111/odi.12654. Epub 2017 Mar 24.
The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with geographic tongue (GT), as compared to control subjects.
An enzyme-linked immunosorbent assay was used to measure the levels of IL-8, EGF and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers.
All patients with GT displayed significantly higher levels of IL-8 than the controls (P < 0.001). The young female patients also showed reduced levels of EGF (P < 0.05) and VEGF (P < 0.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of IL-8 (P < 0.001) and VEGF (P < 0.05) were detected in the patients with GT who also suffered from hypertension.
We consider IL-8 an inflammatory mediator, which contributes to the acute inflammatory response found in GT. EGF and VEGF also seem to be involved in the pathophysiology of GT.
本研究旨在比较地图舌患者和对照组唾液中表皮生长因子（EGF）、血管内皮生长因子（VEGF）和白细胞介素-8（IL-8）的水平。
采用酶联免疫吸附试验检测 34 例地图舌患者和 38 例对照组唾液中 IL-8、EGF 和 VEGF 的水平。根据年龄、性别和全身疾病（可能影响唾液生物标志物水平的因素）将患者和对照组进行分组和匹配。
所有地图舌患者的 IL-8 水平均显著高于对照组（P<0.001）。年轻女性患者的 EGF（P<0.05）和 VEGF（P<0.05）水平也较低，而年轻男性患者则没有观察到这种差异。有趣的是，在同时患有高血压的地图舌患者中，检测到高水平的 IL-8（P<0.001）和 VEGF（P<0.05）。
我们认为 IL-8 是一种炎症介质，有助于解释地图舌中的急性炎症反应。EGF 和 VEGF 似乎也参与了地图舌的病理生理过程。
