McArthur J C, Becker P S, Parisi J E, Trapp B, Selnes O A, Cornblath D R, Balakrishnan J, Griffin J W, Price D
Johns Hopkins Medical Institutions, Baltimore, MD.
Ann Neurol. 1989 Nov;26(5):681-4. doi: 10.1002/ana.410260516.
Early pathological abnormalities in human immunodeficiency virus (HIV-1)-related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV-1-related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.
人类免疫缺陷病毒（HIV-1）相关痴呆早期的病理异常尚未得到充分记录。我们报告了一名患有疲劳和间歇性腹泻的同性恋男性，在多中心艾滋病队列研究的神经学筛查中发现了早期HIV-1相关痴呆。4个月内，他死于大量鼻出血，脑部显示白质星形细胞增多，髓鞘染色轻度苍白，无炎症、多核巨细胞和脑萎缩。
