WNK 激酶信号在离子稳态和人类疾病中的作用。

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

机构信息

Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

Departments of Neurosurgery, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06477, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

出版信息

Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007.

DOI:10.1016/j.cmet.2017.01.007

PMID:28178566

Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

摘要

WNK 激酶及其上游调节物（CUL3/KLHL3）和下游靶标（SPAK/OSR1 激酶和阳离子-Cl 共转运体 [CCCs]）构成了肾脏和神经系统中离子动态平衡所必需的信号级联反应。最近的研究进一步加深了我们对 WNK 在上皮细胞转运、细胞体积动态平衡和 GABA 信号转导中的理解，并揭示了该途径在免疫细胞功能和细胞增殖中的新作用。