Hejazi Sepideh, Masinaei Maryam, Emadzadeh Maryam, Baniassad Shima, Amini Sara, Attaran Soroush, Najafzadeh Mohammad Javad, Attaran Davood, Baniasad Amir
Lung Disease Research Center Mashhad University of Medical Sciences Mashhad Iran.
Clinical Research Development Unit, Ghaem Hospital Mashhad University of Medical Sciences Mashhad Iran.
Pulm Circ. 2025 Apr 7;15(2):e70066. doi: 10.1002/pul2.70066. eCollection 2025 Apr.
Pulmonary artery hypertension (PAH) is a fatal disease associated with high mortality, especially in countries with limited health resources in terms of lack of access to diagnostic and therapeutic evaluations. Therefore, it is necessary to discover inexpensive and available serum biomarkers for examining patients. This study investigates the relationship between PAH patients' six-minute walk (6MWT) distance, serum chloride levels, and mean pulmonary arterial pressure (mPAP). In this cross-sectional study, patients with PAH referring to the pulmonary hypertension clinic of our tertiary hospital were included. Then, the patient's demographic information and clinical findings were recorded, and the serum level of chloride and the 6MWT were examined in the patients. In the present study, 70 PAH patients were evaluated. All patients were female, and the mean age of the patients was 39.44 ± 8.33 years old. Hypochloremia was considered as serum chloride < 97 mmol/L in our study. The mPAP of patients with hypochloremia was significantly higher than non-hypochloremia patients ( < 0.001). The serum chloride levels had a significant positive correlation with the 6MWT distance ( = 0.634, < 0.001). According to the linear regression analysis results, serum chloride level was a significant predictor of 6MWT distance even after adjustment for age and creatinine ( = 0.48; = 0.002). Serum chloride level can be used as an inexpensive method for the evaluation of disease severity in PAH patients, especially in patients with higher time since the diagnosis of PAH.
肺动脉高压（PAH）是一种死亡率很高的致命疾病，尤其是在卫生资源有限、缺乏诊断和治疗评估途径的国家。因此，有必要发现廉价且可用的血清生物标志物来检查患者。本研究调查了PAH患者的六分钟步行（6MWT）距离、血清氯水平和平均肺动脉压（mPAP）之间的关系。在这项横断面研究中，纳入了到我们三级医院肺动脉高压门诊就诊的PAH患者。然后，记录患者的人口统计学信息和临床发现，并检测患者的血清氯水平和6MWT。在本研究中，对70例PAH患者进行了评估。所有患者均为女性，患者的平均年龄为39.44±8.33岁。在我们的研究中，低氯血症被定义为血清氯<97 mmol/L。低氯血症患者的mPAP显著高于非低氯血症患者（<0.001）。血清氯水平与6MWT距离呈显著正相关（=0.634，<0.001）。根据线性回归分析结果，即使在调整年龄和肌酐后，血清氯水平仍是6MWT距离的显著预测因子（=0.48；=0.002）。血清氯水平可作为评估PAH患者疾病严重程度的一种廉价方法，尤其是对于PAH诊断后时间较长的患者。
