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针对2型糖尿病饮食和身体活动的行为改变技术:一项系统评价和荟萃分析。

Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis.

作者信息

Cradock Kevin A, ÓLaighin Gearóid, Finucane Francis M, Gainforth Heather L, Quinlan Leo R, Ginis Kathleen A Martin

机构信息

Physiology, School of Medicine, NUI Galway, University Road, Galway, Ireland.

Electrical & Electronic Engineering, School of Engineering & Informatics, NUI Galway, University Road, Galway, Ireland.

出版信息

Int J Behav Nutr Phys Act. 2017 Feb 8;14(1):18. doi: 10.1186/s12966-016-0436-0.

Abstract

BACKGROUND

Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques (BCTs) and intervention features of dietary and physical activity interventions for patients with type 2 diabetes that are associated with changes in HbA and body weight.

METHODS

We performed a systematic review of papers published between 1975-2015 describing randomised controlled trials (RCTs) that focused exclusively on both diet and physical activity. The constituent BCTs, intervention features and methodological rigour of these interventions were evaluated. Changes in HbA and body weight were meta-analysed and examined in relation to use of BCTs.

RESULTS

Thirteen RCTs were identified. Meta-analyses revealed reductions in HbA at 3, 6, 12 and 24 months of -1.11 % (12 mmol/mol), -0.67 % (7 mmol/mol), -0.28 % (3 mmol/mol) and -0.26 % (2 mmol/mol) with an overall reduction of -0.53 % (6 mmol/mol [95 % CI -0.74 to -0.32, P < 0.00001]) in intervention groups compared to control groups. Meta-analyses also showed a reduction in body weight of -2.7 kg, -3.64 kg, -3.77 kg and -3.18 kg at 3, 6, 12 and 24 months, overall reduction was -3.73 kg (95 % CI -6.09 to -1.37 kg, P = 0.002). Four of 46 BCTs identified were associated with >0.3 % reduction in HbA: 'instruction on how to perform a behaviour', 'behavioural practice/rehearsal', 'demonstration of the behaviour' and 'action planning', as were intervention features 'supervised physical activity', 'group sessions', 'contact with an exercise physiologist', 'contact with an exercise physiologist and a dietitian', 'baseline HbA >8 %' and interventions of greater frequency and intensity.

CONCLUSIONS

Diet and physical activity interventions achieved clinically significant reductions in HbA at three and six months, but not at 12 and 24 months. Specific BCTs and intervention features identified may inform more effective structured lifestyle intervention treatment strategies for type 2 diabetes.

摘要

背景

改变饮食和身体活动行为是2型糖尿病治疗的基石之一,但改变行为具有挑战性。本研究的目的是确定与糖化血红蛋白(HbA)和体重变化相关的2型糖尿病患者饮食和身体活动干预的行为改变技术(BCTs)及干预特征。

方法

我们对1975年至2015年间发表的描述随机对照试验(RCTs)的论文进行了系统评价,这些试验专门聚焦于饮食和身体活动。对这些干预措施的组成BCTs、干预特征和方法学严谨性进行了评估。对HbA和体重的变化进行了荟萃分析,并根据BCTs的使用情况进行了检查。

结果

共确定了13项RCTs。荟萃分析显示,干预组在3、6、12和24个月时HbA的降低幅度分别为-1.11%(12 mmol/mol)、-0.67%(7 mmol/mol)、-0.28%(3 mmol/mol)和-0.26%(2 mmol/mol),与对照组相比,总体降低幅度为-0.53%(6 mmol/mol [95% CI -0.74至-0.32,P < 0.00001])。荟萃分析还显示,在3、6、12和24个月时体重分别降低了-2.7 kg、-3.64 kg、-3.77 kg和-3.18 kg,总体降低幅度为-3.73 kg(95% CI -6.09至-1.37 kg,P = 0.002)。在确定的46项BCTs中,有4项与HbA降低>0.3%相关:“如何进行行为的指导”、“行为实践/排练”、“行为示范”和“行动计划”,干预特征“有监督的身体活动”、“小组会议”、与运动生理学家接触、与运动生理学家和营养师接触、“基线HbA>8%”以及频率和强度更高的干预措施也与之相关。

结论

饮食和身体活动干预在3个月和6个月时使HbA有临床显著降低,但在12个月和24个月时未达到。确定的特定BCTs和干预特征可能为2型糖尿病更有效的结构化生活方式干预治疗策略提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e93/5299734/189c86e4cf89/12966_2016_436_Fig1_HTML.jpg

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