锌原卟啉/血红素比值作为中度早产儿铁状态的参数：前4个月的自然病程及相关性

Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants: natural course and associations in the first 4 months.

作者信息

de Waal C G, Uijterschout L, Abbink M, Boersma B, Vos P, Rövekamp W W, Hudig F, Akkermans M D, van Goudoever J B, Brus F

机构信息

Department of Pediatrics, Juliana Children's Hospital, HAGA Teaching Hospital, The Hague, The Netherlands.

Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

J Perinatol. 2017 Jun;37(6):690-694. doi: 10.1038/jp.2017.3. Epub 2017 Feb 9.

DOI:10.1038/jp.2017.3

PMID:28181998

Abstract

OBJECTIVE

To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.

STUDY DESIGN

ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.

RESULTS

ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).

CONCLUSION

In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.

摘要

目的

确定中晚期早产儿出生后前4个月内锌原卟啉/血红素比值（ZnPP/H）的自然病程及其在检测缺铁（ID）和缺铁性贫血（IDA）中的作用。

研究设计

对161名胎龄为32+0至36+6周、未接受红细胞输血或铁补充剂的荷兰婴儿进行前瞻性队列研究，在出生后1周、6周和4个月时测量ZnPP/H。

结果

ZnPP/H水平在出生后的前6周下降，此后上升。在出生后4个月时，11名（8.5%）患有IDA的婴儿（均值（标准差）：260.8（16.1））的ZnPP/H高于正常婴儿（均值（标准差）：157.3（12.5）），但27名（21.3%）患有ID的婴儿（均值（标准差）：177.0（15.1））的ZnPP/H与正常婴儿无差异。