Mansur A J, de Faria E F, Neves R S, Rett S M, Grinberg M, Bellotti G, Pileggi F
Arq Bras Cardiol. 1989 Jan;52(1):35-7.
Thirty-six patients on chronic anticoagulant therapy were submitted to dental surgery. The ages ranged between 20 and 68 (mean 43.5) years; twenty (55.6%) patients were female and 16 (44.4%) were female. Phenindione was administered to 33 (91.7%) patients, warfarin to one (2.7%) and hydroxycoumarin to two (5.6%). Mechanical heart valve prosthesis occurred in 23 (64%) patients, bioprosthesis in two (5.5%), mitral stenosis submitted to commissurotomy in two (5.5%) and other valvular heart disease occurred in nine patients (25%). Eighty-three elective procedures were performed. Anticoagulant drugs were stopped from two to seven days before, in order to prothrombin time reach 60%. Abnormal bleeding that was easily controlled with local measures occurred in two patients. Sixteen emergency procedures were performed without stopping anticoagulant treatment. Abnormal bleeding was observed in one patient and it subsided after local care. Thus, safe odontologic procedures may be carried on in patients during treatment with oral anticoagulants.
36例接受慢性抗凝治疗的患者接受了牙科手术。年龄在20至68岁之间（平均43.5岁）；20例（55.6%）为女性，16例（44.4%）为男性。33例（91.7%）患者使用苯茚二酮，1例（2.7%）使用华法林，2例（5.6%）使用羟基香豆素。23例（64%）患者有机械心脏瓣膜假体，2例（5.5%）有生物假体，2例（5.5%）二尖瓣狭窄接受了二尖瓣分离术，9例（25%）有其他心脏瓣膜疾病。共进行了83例择期手术。抗凝药物在术前2至7天停用，以使凝血酶原时间达到60%。2例患者出现易于通过局部措施控制的异常出血。16例急诊手术未停用抗凝治疗。1例患者出现异常出血，经局部处理后出血停止。因此，口服抗凝剂治疗期间的患者可以进行安全的牙科手术。
