Horsfall D J, Goldsmith K G, Ricciardelli C, Skinner J M, Tilley W D, Marshall V R
Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia.
Aust N Z J Surg. 1989 Nov;59(11):881-8. doi: 10.1111/j.1445-2197.1989.tb07033.x.
A prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.
本文介绍了一项对57例脑膜瘤中类固醇激素和表皮生长因子受体表达的前瞻性研究。通过放射性配体结合的Scatchard分析确定，20%的脑膜瘤表达经典雌激素受体（ER），但其水平低于通常认可的阳性水平，其余为阴性。使用免疫细胞化学方法在任何脑膜瘤中均未检测到ER。另外，通过Scatchard分析，74%的脑膜瘤显示存在孕激素受体（PR），其特异性不能归因于糖皮质激素或雄激素受体。通过免疫细胞化学染色确定了经典PR的存在。使用免疫细胞化学染色在100%的脑膜瘤中均检测到表皮生长因子受体（EGFR）的存在。这些数据结合先前报道的结果进行了综述，并就药物治疗作为手术辅助手段的潜力进行了讨论。
