Department of Pharmacy, Federal University of Pernambuco, Av. Professor Moraes Rego 1235, 50670-901 Recife, Pernambuco, Brazil.
Department of Pharmacy, Federal University of Pernambuco, Av. Professor Moraes Rego 1235, 50670-901 Recife, Pernambuco, Brazil.
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:245-251. doi: 10.1016/j.msec.2016.12.068. Epub 2016 Dec 16.
This study's aim was to obtain composites from palygorskite (PLG) and chitosan (CS) in order to modify 5-aminosalicylic (5-ASA) release. Initially, the PLG:CS composite was obtained using glutaraldehyde (GLA) as a reticular agent. Then, PLG, CS and PLG:CS were characterized by means of analytical techniques such as CHN elemental analysis, surface area analysis, XRD, FTIR, DSC and TG, SEM, adsorption tests and release profiles. Based on analytical data, the formation of the PLG:CS composite which showed the presence about 19% of CS, decrease in specific surface area, morphological analysis modified, visible change of crystallinity, of FTIR and thermal analysis. In relation to the drug-composite interaction, PLG:CS exhibited a significant increase in adsorption with 5-ASA at 58.24% in relation to PLG and CS which were at 16.29% and 23.96% respectively. The release profiles show that the PLG:CS composite changed the 5-ASA release speed in analyzed simulated fluids (intestinal and stomach) unlike other systems. Thus, the PLG:CS composite with proven synergy of the PLG and CS inherent properties showing 5-ASA effective modified release. Hence, this composite has potential benefits for the vectorization of drugs.
本研究旨在获得凹凸棒石（PLG）和壳聚糖（CS）的复合材料，以修饰 5-氨基水杨酸（5-ASA）的释放。首先，使用戊二醛（GLA）作为网状剂获得 PLG：CS 复合材料。然后，通过 CHN 元素分析、比表面积分析、XRD、FTIR、DSC 和 TG、SEM、吸附试验和释放曲线等分析技术对 PLG、CS 和 PLG：CS 进行了表征。根据分析数据，形成了 PLG：CS 复合材料，其中含有约 19%的 CS，比表面积减小，形态分析发生改变，结晶度可见变化，FTIR 和热分析也发生变化。关于药物-复合材料的相互作用，PLG：CS 与 5-ASA 的吸附能力显著增加，与 PLG 和 CS 相比，分别为 58.24%、16.29%和 23.96%。释放曲线表明，PLG：CS 复合材料改变了在分析模拟流体（肠道和胃）中的 5-ASA 释放速度，与其他系统不同。因此，PLG：CS 复合材料具有 PLG 和 CS 固有特性的协同作用，显示出 5-ASA 的有效控释。因此，这种复合材料具有药物载体化的潜在优势。
