Kim Sungchan, Masud M A, Cho Giphil, Jung Il Hyo
Department of Mathematics, Pusan National University, Busan 46241, Republic of Korea.
Department of Mathematics, Kyungpook National University, Daegu 41566, Republic of Korea.
J Theor Biol. 2017 Apr 21;419:66-76. doi: 10.1016/j.jtbi.2017.02.005. Epub 2017 Feb 7.
In 2005, Lacroix et al. demonstrated that infected humans are more attractive to mosquitoes, a phenomenon known as the vector-bias effect. The aim of this study was to determine how a vector-bias effect affects the changes in the dynamics of malaria transmission, and the changes in control strategies and cost-effectiveness for optimal control considering the regional characteristics or force of infections for different transmission rates. We used a vector-bias mathematical model and considered two different incidence areas: a high transmission area and a low transmission area. Our results showed that the dynamics in the two areas differed; as bias exists and the strategy for optimal control could be changed in the different areas. Thus, this work may give that considering the vector-bias effect in different areas facilitates prediction of the future dynamics and make decisions for establishing controls. We also mention the evolution of malaria parasites in this study.
2005年，拉克鲁瓦等人证明，受感染的人对蚊子更具吸引力，这一现象被称为媒介偏向效应。本研究的目的是确定媒介偏向效应如何影响疟疾传播动态的变化，以及考虑不同传播率的区域特征或感染强度时，控制策略和成本效益的变化，以实现最优控制。我们使用了一个媒介偏向数学模型，并考虑了两个不同的发病地区：高传播地区和低传播地区。我们的结果表明，这两个地区的动态有所不同；由于存在偏向，不同地区的最优控制策略可能会改变。因此，这项工作可能表明，考虑不同地区的媒介偏向效应有助于预测未来动态，并为制定控制措施做出决策。我们在本研究中还提到了疟原虫的进化。
