Mander A J, Young A, MacDonald T M, Williams B C, Waugh C J, Edwards C R
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside, U.K.
Alcohol Alcohol. 1989;24(5):409-14.
Nineteen patients who had been drinking on the day of admission had significantly raised levels of renin, aldosterone and cortisol and a non-significant increase in angiotensin II. Five patients were hypertensive (systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 95 mmHg) at some point during the study and there was a significant tachycardia. Over the first 4 days of abstinence there were falls in all of the measures reaching significance for renin, cortisol, systolic blood pressure and pulse. There were no correlations between blood pressure and any of the hormones measured although there was a significant association between pulse and both aldosterone and cortisol. It is concluded that the activity in the renin-angiotensin axis and hypothalamic-pituitary-adrenal axis is not responsible for alcohol-related changes in blood pressure.
19名入院当天饮酒的患者肾素、醛固酮和皮质醇水平显著升高，血管紧张素II略有升高。5名患者在研究期间的某些时候出现高血压（收缩压大于160 mmHg或舒张压大于95 mmHg），且有明显心动过速。在戒酒的前4天，所有指标均下降，肾素、皮质醇、收缩压和脉搏下降显著。血压与所测任何一种激素之间均无相关性，尽管脉搏与醛固酮和皮质醇均有显著关联。结论是，肾素-血管紧张素轴和下丘脑-垂体-肾上腺轴的活性与酒精相关的血压变化无关。
