Ma Fushun, Zhai Zhaohui, Zhu Shunwen, Tang Shengjian
Plastic Surgery Hospital of Weifang Medical University, 288 Shenglidongjie Kuiwen Weifang, Shandong, People's Republic of China, 261042.
Muscle Nerve. 2018 Jan;57(1):96-99. doi: 10.1002/mus.25609. Epub 2017 Apr 8.
Botulinum neurotoxin A (BoNTA) has long been used as a therapeutic agent and has been widely accepted as a cosmetic agent in recent years. It can inhibit function and induce structural changes in skeletal muscle.
Specimens of fresh dissected human masseter muscle were used to observe the ultrastructural changes that occurred at 6 and 12 months following BoNTA injection.
The findings observed were muscle fiber distortion, sarcomere shortening, mitochondrial vacuolar degeneration, glycogen accumulation, and H and M band disruption in the triad of tubules. At 12 months after injection, there was still evidence of degenerative changes in muscle ultrastructure, whereas most organelles exhibited a normal structure.
Profound ultrastructural and organelle disfiguring changes were observed after BoNTA injection into human masseter muscle. Most changes were transient, however, and were resolved by 12 months after injection. Muscle Nerve 57: 96-99, 2018.
肉毒杆菌神经毒素A（BoNTA）长期以来一直被用作治疗药物，近年来已被广泛用作美容药物。它可以抑制骨骼肌的功能并诱导其结构变化。
使用新鲜解剖的人咬肌标本观察BoNTA注射后6个月和12个月时发生的超微结构变化。
观察到的结果包括肌纤维扭曲、肌节缩短、线粒体空泡变性、糖原积累以及小管三联体中的H带和M带破坏。注射后12个月，肌肉超微结构仍有退行性变化的迹象，而大多数细胞器呈现正常结构。
将BoNTA注射到人咬肌后观察到了深刻的超微结构和细胞器变形变化。然而，大多数变化是短暂的，在注射后12个月时得到解决。《肌肉与神经》57: 96 - 99, 2018年。
