Imagerie et Stratégies Thérapeutiques de la Schizophrénie (ISTS), Normandie Univ, UNICAEN, Faculté de médecine, Caen F-14000, France.
Normandie Univ, UNICAEN, CNRS UMS 3408, GIP Cyceron, Caen F-14000, France.
Schizophr Res. 2017 Nov;189:142-145. doi: 10.1016/j.schres.2017.01.049. Epub 2017 Feb 8.
This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network.
这项探索性研究调查了伴有幻听的精神分裂症患者（SZ）的语言网络中的功能连接（FC），以及 rTMS 对其的治疗效果。11 名伴有幻听的 SZ 患者和 10 名健康对照（HC）接受了使用语音聆听范式的两次 fMRI 扫描。SZ 在第一次 fMRI 扫描后接受了 20Hz rTMS 治疗。与 HC 相比，SZ 表现出语言网络中 FC 的减少。虽然幻听在 12 天后得到改善，但 FC 没有变化。这表明高频 rTMS 对幻听的疗效，而 rTMS 对语言网络内 FC 没有任何影响。
