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贲门失弛缓症的治疗现状:诊断与治疗综述

Current status of achalasia management: a review on diagnosis and treatment.

作者信息

Tuason Joshua, Inoue Haruhiro

机构信息

Digestive Disease Center, Showa University Koto-Toyosu Hospital, 5-1-38 Toyosu, Koto-Ku, Tokyo, 135-8577, Japan.

出版信息

J Gastroenterol. 2017 Apr;52(4):401-406. doi: 10.1007/s00535-017-1314-5. Epub 2017 Feb 10.

Abstract

BACKGROUND

Achalasia is a rare esophageal motility disorder that is characterized by loss of peristalsis and failure of relaxation of the lower esophageal sphincter (LES), particularly during swallowing. This review focuses on the diagnosis of esophageal motility disorders as defined by the Chicago Classification ver 3.0, and presents management options with regard to per-oral endoscopic myotomy (POEM) as the treatment of choice.

METHODS

A concise review of literature was performed for articles related to the management of achalasia, and this was contrasted with our institution's current practice.

RESULTS

Achalasia is still incompletely understood, and management is focused on establishing a proper diagnosis, and relieving the obstructive symptoms.

CONCLUSIONS

Achalasia should be considered when dysphagia is present, and not otherwise caused by an obstruction or inflammation, and when criteria is met as per the Chicago Classification ver 3.0. Lowering LES tone and disruption of LES can be accomplished by various methods, most notably pneumatic balloon dilatation and surgical myotomy. POEM has been gaining momentum as a first line therapy for achalasia symptoms, and can be considered an important tool for motility disorders of the esophagus.

摘要

背景

贲门失弛缓症是一种罕见的食管动力障碍性疾病,其特征是蠕动消失以及食管下括约肌(LES)松弛功能障碍,尤其是在吞咽时。本综述聚焦于《芝加哥分类法》第3.0版所定义的食管动力障碍的诊断,并介绍了以经口内镜下肌切开术(POEM)作为首选治疗方法的管理方案。

方法

对与贲门失弛缓症管理相关的文章进行了简要的文献综述,并与我们机构目前的实践进行了对比。

结果

贲门失弛缓症仍未被完全理解,管理重点在于确立正确诊断并缓解梗阻症状。

结论

当出现吞咽困难且并非由梗阻或炎症引起,并且符合《芝加哥分类法》第3.0版的标准时,应考虑贲门失弛缓症。降低LES张力和破坏LES可通过多种方法实现,最显著的是气囊扩张术和手术肌切开术。POEM作为治疗贲门失弛缓症症状的一线疗法已越来越受到关注,可被视为治疗食管动力障碍的重要工具。

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