Elliott Kevin C, Wu Wei, Bertram Richard, Hyson Richard L, Johnson Frank
Program in Neuroscience and Department of Psychology, Florida State University, Tallahassee, Florida.
Program in Neuroscience and Department of Statistics, Florida State University, Tallahassee, Florida.
J Comp Neurol. 2017 Jun 15;525(9):2133-2151. doi: 10.1002/cne.24189. Epub 2017 Mar 30.
Neural activity within the cortical premotor nucleus HVC (acronym is name) encodes the learned songs of adult male zebra finches (Taeniopygia guttata). HVC activity is driven and/or modulated by a group of five afferent nuclei (the Medial Magnocellular nucleus of the Anterior Nidopallium, MMAN; Nucleus Interface, NIf; nucleus Avalanche, Av; the Robust nucleus of the Arcopallium, RA; the Uvaeform nucleus, Uva). While earlier evidence suggested that HVC receives a uniformly distributed and nontopographic pattern of afferent input, recent evidence suggests this view is incorrect (Basista et al., ). Here, we used a double-labeling strategy (varying both the distance between and the axial orientation of dual tracer injections into HVC) to reveal a massively parallel and in some cases topographic pattern of afferent input. Afferent neurons target only one rostral or caudal location within medial or lateral HVC, and each HVC location receives convergent input from each afferent nucleus in parallel. Quantifying the distributions of single-labeled cells revealed an orthogonal topography in the organization of afferent input from MMAN and NIf, two cortical nuclei necessary for song learning. MMAN input is organized across the lateral-medial axis whereas NIf input is organized across the rostral-caudal axis. To the extent that HVC activity is influenced by afferent input during the learning, perception, or production of song, functional models of HVC activity may need revision to account for the parallel input architecture of HVC, along with the orthogonal input topography of MMAN and NIf.
皮质前运动核HVC（首字母缩写即其名称）内的神经活动编码成年雄性斑胸草雀（Taeniopygia guttata）习得的歌声。HVC的活动由一组五个传入核团驱动和/或调节（前巢皮质内侧大细胞核，MMAN；界面核，NIf；雪崩核，Av；弓状皮质粗壮核，RA；葡萄状核，Uva）。虽然早期证据表明HVC接收的是均匀分布且无拓扑结构的传入输入模式，但最近的证据表明这种观点是错误的（巴西斯塔等人， ）。在这里，我们使用了一种双重标记策略（改变双重示踪剂注入HVC的距离和轴向）来揭示传入输入的大规模平行且在某些情况下具有拓扑结构的模式。传入神经元仅靶向内侧或外侧HVC内的一个喙侧或尾侧位置，并且每个HVC位置并行接收来自每个传入核团的汇聚输入。对单标记细胞分布的量化揭示了来自MMAN和NIf（歌曲学习所需的两个皮质核团）的传入输入组织中的正交拓扑结构。MMAN的输入沿外侧-内侧轴组织，而NIf的输入沿喙侧-尾侧轴组织。就HVC活动在歌曲学习、感知或产生过程中受到传入输入的影响而言，HVC活动的功能模型可能需要修订，以考虑HVC的平行输入架构以及MMAN和NIf的正交输入拓扑结构。
