Benoliel R, Sharav Y, Haviv Y, Almoznino G
Rutgers School of Dental Medicine, Rutgers State University of New Jersey, Newark, NJ, USA.
Department of Oral Medicine, The Faculty of Dentistry, Hebrew University-Hadassah, Jerusalem, Israel.
Headache. 2017 Jun;57(6):997-1009. doi: 10.1111/head.13040. Epub 2017 Feb 11.
Classical trigeminal neuralgia (CTN) and the short-lasting unilateral neuralgiform headache attacks (SUNHA) are clinically similar.
The SUNHAs include short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). Shared clinical signs with CTN include severe, unilateral trigeminal pain that is often triggered by innocuous stimuli and accompanied by a dull persistent background pain. Recent reports on trigeminal neuralgia cases with atypical features such as autonomic signs and prolonged attack duration further blur the clinical distinction between CTN and SUNHAs.
Are the similarities greater than their differences? If so, this may reflect a spectrum of disease ranging from typical CTN attacks to typical SUNHAs with a mixed phenotype in the middle. In this review they will summarize the overlap between these entities and contrast the pathophysiology and treatment approach.
经典三叉神经痛（CTN）与短暂性单侧神经痛样头痛发作（SUNHA）在临床上相似。
SUNHA包括伴有结膜充血和流泪的短暂性单侧神经痛样头痛发作（SUNCT）以及伴有颅自主神经症状的短暂性单侧神经痛样头痛发作（SUNA）。与CTN的共同临床体征包括严重的单侧三叉神经疼痛，常由无害刺激触发，并伴有持续性钝痛。最近关于具有自主神经体征和发作持续时间延长等非典型特征的三叉神经痛病例的报告进一步模糊了CTN与SUNHA之间的临床区别。
它们的相似性是否大于差异性？如果是这样，这可能反映了一系列疾病，从典型的CTN发作到典型的SUNHA，中间存在混合表型。在这篇综述中，他们将总结这些疾病之间的重叠，并对比其病理生理学和治疗方法。
