Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Department of Pediatrics, Chonnam National University Hospital, Gwangju, South Korea.
Environ Res. 2017 May;155:60-63. doi: 10.1016/j.envres.2017.01.030. Epub 2017 Feb 9.
In South Korea, a cluster of humidifier disinfectant-induced lung injury (HDLI) cases developed between 2006 and 2011. There are no existing reports regarding the rate of humidifier disinfectant (HD) usage in the general population of Korean children. The purpose of this study was to investigate the rate of humidifier and HD usage in the general population of Korean children. This is a general population-based birth cohort multicenter study, Panel Study of Korean Children (PSKC) from 2008, a humidifier and HD-related questionnaire administered to 1577 subjects (809 male, 768 female) in 2015 (n=1577). The questionnaire consisted of four categories (humidifier usage, HD usage, exposure duration, and type of HD brands). A total of 75.6% (1192/1577) had used a humidifier, and the rate of HD usage was found to be 31.1% (409/1316). Polyhexamethylene guanidine (PHMG), used as a disinfectant, was found to have the highest usage rate (62.0%). HD was used for less than 3 months of the entire lifetime of most of the subjects. In conclusion, approximately 30% of young Korean children were exposed to HD. PHMG-containing HD was the most commonly used. These results suggest that a nationwide epidemiologic investigation is needed urgently, and children exposed to HD should be investigated regarding their status of lung injury, including a pulmonary function test. Moreover, a long-term follow-up period may be required to evaluate HD usage-associated lung injury.
在韩国，2006 年至 2011 年间发生了一批加湿器消毒剂诱发的肺损伤（HDLI）病例。目前尚无关于韩国儿童普通人群中加湿器消毒剂（HD）使用情况的报告。本研究旨在调查韩国儿童普通人群中加湿器和 HD 的使用情况。这是一项基于人群的出生队列多中心研究，即 2008 年的韩国儿童面板研究（PSKC），于 2015 年对 1577 名受试者（809 名男性，768 名女性）进行了与加湿器和 HD 相关的问卷调查（n=1577）。问卷包括四个类别（加湿器使用情况、HD 使用情况、暴露持续时间和 HD 品牌类型）。共有 75.6%（1192/1577）的人使用过加湿器，HD 的使用率为 31.1%（409/1316）。作为消毒剂使用的聚六亚甲基胍（PHMG）使用率最高（62.0%）。HD 的使用时间不到大多数受试者整个生命期的 3 个月。总之，约 30%的韩国年轻儿童接触过 HD。含 PHMG 的 HD 是最常用的。这些结果表明，迫切需要进行全国性的流行病学调查，应该对接触 HD 的儿童进行肺部损伤状况的调查，包括肺功能检查。此外，可能需要进行长期随访，以评估与 HD 使用相关的肺部损伤。
