Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea.
Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Sci Total Environ. 2018 Mar;616-617:855-862. doi: 10.1016/j.scitotenv.2017.10.237. Epub 2017 Nov 7.
Children aged ≤6years reportedly account for 52% of victims of humidifier disinfectant-associated lung injuries.
To evaluate the association of humidifier disinfectants with lung injury risk among children aged ≤6years.
Patients with humidifier disinfectant-associated lung injuries (n=214) who were clinically evaluated to have a definite (n=108), probable (n=49), or possible (n=57) association with humidifier disinfectants as well as control patients (n=123) with lung injury deemed unlikely to be associated with humidifier disinfectant use were evaluated to determine factors associated with increased risk of humidifier disinfectant-associated lung injury using unconditional multiple logistic regression analysis.
For estimated airborne humidifier disinfectant concentrations, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in a dose-dependent manner in the highest quartile (Q4, 135-1443μg/m) compared with that in the lowest quartile (Q1, ≤33μg/m). Registered patients using more than two humidifier disinfectant brands were at an increased risk of humidifier disinfectant-associated lung injury (adjusted OR, 2.2; 95% confidence interval, 1.3-3.8) compared with those using only one brand. With respect to the duration of humidifier disinfectant use, risk of humidifier disinfectant-associated lung injury increased ≥two-fold in the lowest quartile (≤5months) compared with that in the highest quartile (≥14months; adjusted OR 0.3; 95% confidence interval, 0.2-0.6).
Younger children are more vulnerable to HDLI when exposed to HD chemicals within short period in early life.
据报道，≤6 岁的儿童占加湿器消毒剂相关肺损伤患者的 52%。
评估加湿器消毒剂与≤6 岁儿童肺损伤风险的关系。
对 214 例加湿器消毒剂相关肺损伤患者（临床评估为明确（n=108）、可能（n=49）或可能（n=57）与加湿器消毒剂相关）和 123 例肺损伤患者（n=123）进行评估，认为与加湿器消毒剂使用无关，以确定与加湿器消毒剂相关的肺损伤风险增加的相关因素使用非条件多变量逻辑回归分析。
对于估计的空气传播加湿器消毒剂浓度，与最低四分位数（Q1，≤33μg/m）相比，最高四分位数（Q4，135-1443μg/m）中加湿器消毒剂相关肺损伤的风险呈剂量依赖性增加≥两倍。与仅使用一种品牌相比，使用超过两种加湿器消毒剂品牌的患者患加湿器消毒剂相关肺损伤的风险增加（调整比值比，2.2；95%置信区间，1.3-3.8）。就加湿器消毒剂使用时间而言，与最高四分位数（≥14 个月）相比，最低四分位数（≤5 个月）中加湿器消毒剂相关肺损伤的风险增加≥两倍（调整比值比，0.3；95%置信区间，0.2-0.6）。
年幼的儿童在生命早期短时间内接触 HD 化学物质时，更容易受到 HDLI 的影响。
