[有机汞中毒大鼠血脑屏障的观察：钆喷酸葡胺增强磁共振研究]
[The observation of blood-brain barrier of organic mercury poisoned rat: a Gd-DTPA enhanced magnetic resonance study].
作者信息
Kuwabara T, Yuasa T, Hidaka K, Igarashi H, Kaneko K, Miyatake T
机构信息
Department of Neurology, Niig ata University, Japan.
出版信息
No To Shinkei. 1989 Jul;41(7):681-5.
Permeability of the blood-brain barrier (BBB) of methylmercury chloride (MMC) intoxicated rat brain was studied in vivo by gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) enhanced magnetic resonance imaging (MRI), measuring the longitudinal relaxation time (T1) and the transverse relaxation time (T2). MMC intoxicated rat brain showed the prolonged T1 in the cerebral white matter and prolonged T2 in the cerebellar cortex. After Gd-DTPA administration, T1 of cerebral and cerebellar white matter shortened from 1.647 to 1.344 sec., and 1.290 to 1.223 sec. respectively. On the contrary, T2 showed no change after Gd-DTPA injection. It was concluded that, although the shortening of T1 after Gd-DTPA enhancement was rather little when compared with experimental brain ischemia, the shortening of the relaxation time of the MMC intoxicated rat brain was caused by the increased permeability of BBB.
通过钆二乙烯三胺五乙酸（Gd-DTPA）增强磁共振成像（MRI），在体内研究了氯化甲基汞（MMC）中毒大鼠脑血脑屏障（BBB）的通透性，测量了纵向弛豫时间（T1）和横向弛豫时间（T2）。MMC中毒大鼠脑显示脑白质T1延长，小脑皮质T2延长。给予Gd-DTPA后，脑白质和小脑白质的T1分别从1.647秒缩短至1.344秒和从1.290秒缩短至1.223秒。相反，注射Gd-DTPA后T2无变化。得出的结论是，尽管与实验性脑缺血相比，Gd-DTPA增强后T1的缩短幅度较小，但MMC中毒大鼠脑弛豫时间的缩短是由BBB通透性增加引起的。
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