Miller Heather, Panahi Ladan, Tapia Daniel, Tran Andrew, Bowman John D
J Am Pharm Assoc (2003). 2017 Mar-Apr;57(2S):S45-S50. doi: 10.1016/j.japh.2016.12.079. Epub 2017 Feb 8.
The epidemic of opioid prescription deaths in recent years resulted in the recent rescheduling of hydrocodone-containing products to restrict access to them. Opioid users have recognized that loperamide can ameliorate withdrawal symptoms and also produce euphoria in very high doses. This article discusses the potential for loperamide misuse and abuse and examines trends in the increasing number of published cases of loperamide toxicity.
PubMed was used to search MEDLINE for case reports of loperamide abuse.
United States.
Numbers of cases of loperamide misuse, characteristics of patients, reported toxicities.
From 1985 to 2016, 54 case reports of loperamide toxicity were published, with 21 cases between 1985 and 2013 and 33 cases between 2014 and 2016. In addition, 179 cases of intentional loperamide misuse were reported to the National Poison Database System between 2008 and 2016, with more than half reported after January 1, 2014.
Loperamide misuse and abuse is increasing in the United States, and pharmacists are encouraged to monitor and restrict their sales.
近年来阿片类药物处方致死的流行导致含氢可酮产品最近重新分类，以限制其获取。阿片类药物使用者已认识到洛哌丁胺可缓解戒断症状，且在极高剂量时也会产生欣快感。本文讨论了洛哌丁胺滥用的可能性，并研究了已发表的洛哌丁胺中毒病例数量增加的趋势。
使用PubMed在MEDLINE中搜索洛哌丁胺滥用的病例报告。
美国。
洛哌丁胺滥用病例数、患者特征、报告的毒性。
1985年至2016年，共发表了54例洛哌丁胺中毒病例报告，1985年至2013年有21例，2014年至2016年有33例。此外，2008年至2016年期间，国家毒物数据库系统共收到179例故意滥用洛哌丁胺的报告，其中一半以上是在2014年1月1日之后报告的。
在美国，洛哌丁胺的滥用现象正在增加，鼓励药剂师监测并限制其销售。
