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Corrigendum to "Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice" [Toxicol. Appl. Pharmacol. 316 (2017) 74-82].

作者信息

Choi You-Jin, Lee Kang-Yo, Jung Seung-Hwan, Kim Hyung Sik, Shim Gayong, Kim Mi-Gyeong, Oh Yu-Kyoung, Oh Seon-Hee, Jun Dae Won, Lee Byung-Hoon

机构信息

College of Pharmacy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.

School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.

出版信息

Toxicol Appl Pharmacol. 2017 Apr 1;320:73. doi: 10.1016/j.taap.2017.02.005. Epub 2017 Feb 8.

DOI:10.1016/j.taap.2017.02.005
PMID:28189653
Abstract
摘要

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Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.小檗碱激活AMPK通过上调脂肪酸转运蛋白CD36诱导小鼠肝脏脂质蓄积。
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Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17].
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Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.肝脂肪酸易位蛋白 CD36 的上调与非酒精性脂肪性肝炎和慢性丙型肝炎中的胰岛素抵抗、高胰岛素血症和脂肪变性增加有关。
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AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36.AMPK介导的心肌长链脂肪酸摄取增加严重依赖于肌膜CD36。
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Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.高脂喂养大鼠后，脂肪酸转运和肌细胞内脂质蓄积急剧增加，但胰岛素抵抗明显延迟出现。
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Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity.小檗碱通过控制中枢和外周的AMPK活性改善肥胖中的脂质失调。
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Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs.膳食α-生育酚和阿托伐他汀可减少高脂诱导的豚鼠肝脏脂质积累并下调CD36蛋白。
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