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以及苦参碱的镇静作用。 （注：原文中“of and Matrine”表述不完整，可能存在信息缺失）

Sedative Effect of and Matrine.

作者信息

Lee Hyun-Ju, Lee Sun-Young, Jang Daehyuk, Chung Sun-Yong, Shim Insop

机构信息

Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul 02435, Republic of Korea.

Department of Oriental Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul 05278, Republic of Korea.

出版信息

Biomol Ther (Seoul). 2017 Jul 1;25(4):390-395. doi: 10.4062/biomolther.2016.156.

DOI:10.4062/biomolther.2016.156
PMID:28190318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5499617/
Abstract

The present study investigated the sedative effects of and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method and enzyme-linked immunosorbent assay. The results showed that and matrine administration had an effect on normalization of caffeine-induced hyperactivity and promoting a shift toward non-rapid eye movement (NREM) sleep. c-Fos-immunoreactivity and 5-HT level in the ventrolateral preoptic nucleus (VLPO), a sleep promoting region, were increased in the both and matrine-injected groups. In conclusion, and its bioactive compound, matrine alleviated caffeine-induced hyperactivity and promoted NREM sleep by activating VLPO neurons and modulating serotonergic transmission. It is suggested that might be a useful natural alternatives for hypnotic medicine.

摘要

本研究通过对大鼠进行运动活动测试和脑电图（EEG）分析，研究了[具体物质未提及]及其生物活性化合物苦参碱的镇静作用。利用免疫组织化学方法和酶联免疫吸附测定法评估大脑中的c-Fos免疫反应性和血清素（5-HT），确定了它们有益作用的潜在神经机制。结果表明，给予[具体物质未提及]和苦参碱对咖啡因诱导的多动有正常化作用，并促进向非快速眼动（NREM）睡眠的转变。在注射了[具体物质未提及]和苦参碱的两组中，促进睡眠区域腹外侧视前核（VLPO）中的c-Fos免疫反应性和5-HT水平均升高。总之，[具体物质未提及]及其生物活性化合物苦参碱通过激活VLPO神经元和调节血清素能传递，减轻了咖啡因诱导的多动并促进了NREM睡眠。提示[具体物质未提及]可能是催眠药物有用的天然替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/1b594f5c12e1/bt-25-390f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/1e152c5ec8b1/bt-25-390f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/59d6b9e247d5/bt-25-390f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/25620b7a31c9/bt-25-390f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/1b594f5c12e1/bt-25-390f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/1e152c5ec8b1/bt-25-390f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/59d6b9e247d5/bt-25-390f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/25620b7a31c9/bt-25-390f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ca/5499617/1b594f5c12e1/bt-25-390f4.jpg

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