Redington Jennifer M, Breydo Leonid, Uversky Vladimir N
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612. United States.
USF Health Byrd Alzheimer`s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612. United States.
Protein Pept Lett. 2017;24(4):340-347. doi: 10.2174/0929866524666170209153421.
Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.
蛋白质疗法在多种人类疾病的治疗中发挥着越来越重要的作用。然而，与其他蛋白质一样，它们容易发生聚集。蛋白质类药物的聚集会导致疗效丧失，并可能引发细胞毒性和免疫原性反应。本文综述了蛋白质疗法聚集的各种方式以及为预防或尽量减少这一过程所采取的多种方法。
