Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Exp Dermatol. 2017 Oct;26(10):955-957. doi: 10.1111/exd.13317. Epub 2017 May 2.
The expression of filaggrin in differentiated keratinocytes and the association of filaggrin mutations with ichthyosis vulgaris and atopic dermatitis suggest that this prototypical member of the S100 fused-type protein (SFTP) family plays a key role in the epidermal barrier to the environment. Here, we report that SFTP genes are present not only in amniotes but also in amphibians. Four SFTPs are expressed in the skin of the frog Xenopus laevis. The results of this study indicate that filaggrin has evolved from an ancestral SFTP that may have contributed to skin modifications during the evolutionary transition to terrestrial life.
丝聚合蛋白在分化的角蛋白细胞中的表达以及丝聚合蛋白突变与寻常型鱼鳞病和特应性皮炎的关联表明，这种 S100 融合型蛋白 (SFTP) 家族的典型成员在表皮与环境的屏障中起着关键作用。在这里，我们报告不仅在羊膜动物中，而且在两栖动物中也存在 SFTP 基因。在青蛙非洲爪蟾的皮肤中表达了 4 种 SFTP。本研究结果表明，丝聚合蛋白是从可能有助于向陆地生活进化过程中皮肤改变的祖先 SFTP 进化而来的。
