芬诺斯坎迪亚地区棕背䶄（Myodes glareolus）中吕根病毒的分布与季节变化
DISTRIBUTION AND SEASONAL VARIATION OF LJUNGAN VIRUS IN BANK VOLES (MYODES GLAREOLUS) IN FENNOSCANDIA.
作者信息
Fevola Cristina, Rossi Chiara, Rosà Roberto, Nordström Åke, Ecke Frauke, Magnusson Magnus, Miller Andrea L, Niemimaa Jukka, Olsson Gert E, Jääskeläinen Anne J, Hörnfeldt Birger, Henttonen Heikki, Hauffe Heidi C
机构信息
1 Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, Via Edmund Mach 1, I-38010 San Michele all'Adige (TN), Italy.
2 Department of Virology and Immunology, University of Helsinki and Helsinki University Hospital (HUSLAB), Box 720, FI-00029 HUS, Finland.
出版信息
J Wildl Dis. 2017 Jul;53(3):552-560. doi: 10.7589/2016-06-145. Epub 2017 Feb 13.
Ljungan virus (LV) is a picornavirus originally isolated from Swedish bank voles ( Myodes glareolus ) in 1998. The association of LV with human disease has been debated ever since, but fundamental data on the ecology of the virus are still lacking. Here we present results of the first intensive study on the prevalence of LV in bank voles trapped in Fennoscandia (Sweden and Finland) from 2009-12 as determined by PCR. Using an LV-specific real-time reverse transcriptase PCR, LV was detected in the liver of 73 out of 452 (16.2%) individuals and in 13 out of 17 sampling sites across Sweden and Finland (mean per site prevalence 16%, SE 3%, range 0-50%). We found more infected animals in autumn compared to spring, and lighter and heavier individuals had a higher prevalence than those with intermediate body masses. The result that LV prevalence is also lower in heavier (i.e., older) animals suggests for the first time that LV infection is not persistent in rodents.
吕宋病毒（LV）是一种小核糖核酸病毒，于1998年最初从瑞典田鼠（黄毛鼠）中分离出来。从那时起，LV与人类疾病的关联就一直存在争议，但关于该病毒生态学的基础数据仍然缺乏。在此，我们展示了对2009年至2012年在斯堪的纳维亚半岛（瑞典和芬兰）捕获的田鼠中LV流行情况进行的首次深入研究结果，该结果通过聚合酶链反应（PCR）测定。使用LV特异性实时逆转录聚合酶链反应，在452只个体中的73只（16.2%）的肝脏中检测到LV，并且在瑞典和芬兰的17个采样点中的13个采样点检测到LV（每个采样点的平均流行率为16%，标准误差为3%，范围为0 - 50%）。我们发现与春季相比，秋季感染的动物更多，并且体重较轻和较重的个体的流行率高于体重中等的个体。较重（即较老）动物中LV流行率也较低的结果首次表明LV感染在啮齿动物中不是持续性的。
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