Cain Derek W, Cidlowski John A
Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Nat Rev Immunol. 2017 Apr;17(4):233-247. doi: 10.1038/nri.2017.1. Epub 2017 Feb 13.
Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.
内源性糖皮质激素对包括代谢、发育和炎症在内的各种生理过程至关重要。自1948年以来，合成糖皮质激素一直被用于治疗各种免疫相关疾病。这些激素免疫抑制特性的潜在机制已受到深入研究，人们普遍认识到糖皮质激素对免疫系统具有多效性作用。然而，糖皮质激素作用的细胞和分子基础仍不清楚。在本综述中，我们提炼了几十年来激烈（且常常相互矛盾）的研究，这些研究界定了内分泌应激反应与免疫系统之间的界面。
