Kubota K, Yanagisawa T, Kurabayashi H, Ono K, Shirakura T, Nagashima K, Yatabe H, Nakazato Y
Department of Medicine, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
Blut. 1989 Nov;59(5):458-9. doi: 10.1007/BF00349068.
A 43-year-old male patient with hypercalcemia and osteolytic lesions complicating chronic myelogenous leukemia is presented. Extramedullary myeloid blastic crisis was diagnosed by the histological finding of the specimen biopsied from a osteolytic lesion in the right femur. As the serum levels of parathyroid hormone, 1,25 (OH)2 vitamin D, prostaglandin E2 and interleukin 1, and the urinary excretion of cyclic AMP were all normal, it was considered that the hypercalcemia was attributed to the bone destruction by the invasion of leukemic myeloblasts.
本文报告了一名43岁男性慢性粒细胞白血病患者，伴有高钙血症和溶骨性病变。通过对右股骨溶骨性病变活检标本的组织学检查诊断为髓外髓系母细胞危象。由于甲状旁腺激素、1,25(OH)2维生素D、前列腺素E2和白细胞介素1的血清水平以及环磷酸腺苷的尿排泄均正常，因此认为高钙血症是由于白血病原始粒细胞浸润导致的骨质破坏所致。
