Jockwitz Christiane, Caspers Svenja, Lux Silke, Eickhoff Simon B, Jütten Kerstin, Lenzen Stefan, Moebus Susanne, Pundt Noreen, Reid Andrew, Hoffstaedter Felix, Jöckel Karl-Heinz, Erbel Raimund, Cichon Sven, Nöthen Markus M, Shah N Jon, Zilles Karl, Amunts Katrin
Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
Institute of Neuroscience and Medicine (INM-1,4), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany.
Cortex. 2017 Apr;89:28-44. doi: 10.1016/j.cortex.2017.01.008. Epub 2017 Jan 23.
Aging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55-85 years) from the 1000BRAINS project. The executive, left and right frontoparietal resting-state (RS) networks showed age-related increases in RSFC. However, older adults did not show changes in RSFC in the default mode network (DMN). Furthermore, lower performance in working memory (WM) was associated with higher RSFC in the left frontoparietal RS network. The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance. Nevertheless, the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults. Consequently, the current results provide evidence for a functional reorganization of the brain until late adulthood that might additionally explain parts of the variability of cognitive abilities in older adults.
衰老会导致大脑结构和认知能力的整体变化，以及功能性脑网络的重组。重要的是，这些与年龄相关的变化在老年受试者中表现出更高的个体间变异性。特别关注这种变异性是从成年早期到晚期的终生轨迹研究面临的一项挑战。因此，本研究专门聚焦于成年晚期，以表征来自1000BRAINS项目的711名老年人（55 - 85岁）静息态网络（RSFC）中的功能连接性与年龄和认知能力之间的关系。执行、左和右额顶叶静息态（RS）网络显示出与年龄相关的RSFC增加。然而，老年人在默认模式网络（DMN）中的RSFC没有变化。此外，工作记忆（WM）表现较低与左额顶叶RS网络中较高的RSFC相关。结果表明，RSFC与年龄相关的代偿性增加可能有助于维持认知能力。尽管如此，RSFC与WM表现之间的负相关暗示了表现较差的老年人认知储备能力有限。因此，目前的结果为大脑直到成年晚期的功能重组提供了证据，这可能进一步解释了老年人认知能力变异性的部分原因。
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