[在患有重度抑郁症的哥伦比亚人群样本中对色氨酸羟化酶2基因的三种多态性进行表征]
[Characterisation of three polymorphisms of the tryptophan hydroxylase 2 gene in a sample of Colombian population with major depressive disorder].
作者信息
Martínez-Idárraga Adriana, Riveros-Barrera Irene, Sánchez Ricardo, Jaramillo Luis Eduardo, Calvo-Gómez José Manuel, Yunis-Londoño Juan José
机构信息
Departamento de Psiquiatría, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Grupo de Patología Molecular, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.
出版信息
Rev Colomb Psiquiatr. 2017 Jan-Mar;46(1):22-30. doi: 10.1016/j.rcp.2016.03.007. Epub 2016 May 16.
OBJECTIVE
Identify whether rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene, are associated with a major depressive disorder in a sample of the Colombian population.
METHODS
Case-control study was conducted in which a comparison was made between subjects diagnosed with major depressive disorder at some point in adulthood or active symptoms at the time of evaluation, and subjects with no psychiatric disease. Subjects were studied in the Department of Psychiatry, Faculty of Medicine and the Institute of Genetics at the National University of Colombia. Polymorphisms were genotyped using Taqman probes in real time PCR. As well as studying the association between major depressive disorder and these (single nucleotide polymorphisms (SNPs), the association with other factors previously associated with depression were also analysed.
RESULTS
No statistically significant association between genotypic and allelic frequencies of each polymorphism and major depressive disorder was found. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed. Association between sex and complication during pregnancy / childbirth and major depressive disorder was observed.
CONCLUSIONS
There was no association between any polymorphism and major depressive disorder.
目的
在哥伦比亚人群样本中，确定色氨酸羟化酶2基因的rs11179000、rs136494和rs4570625多态性是否与重度抑郁症相关。
方法
进行病例对照研究，将成年期某一时刻被诊断为重度抑郁症或评估时出现活动症状的受试者与无精神疾病的受试者进行比较。研究对象来自哥伦比亚国立大学医学院精神病学系和遗传学研究所。使用Taqman探针通过实时PCR对多态性进行基因分型。除了研究重度抑郁症与这些单核苷酸多态性（SNP）之间的关联外，还分析了与先前与抑郁症相关的其他因素的关联。
结果
未发现每种多态性的基因型和等位基因频率与重度抑郁症之间存在统计学上的显著关联。观察到性别与妊娠/分娩期间的并发症和重度抑郁症之间的关联。观察到性别与妊娠/分娩期间的并发症和重度抑郁症之间的关联。
结论
任何多态性与重度抑郁症之间均无关联。
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