克罗卡林对豚鼠离体气管中胆碱能神经刺激诱发的支气管收缩的影响。
Effect of cromakalim on bronchoconstriction evoked by cholinergic nerve stimulation in guinea-pig isolated trachea.
作者信息
McCaig D J, De Jonckheere B
机构信息
School of Pharmacy, Robert Gordon's Institute of Technology, Schoolhill, Aberdeen.
出版信息
Br J Pharmacol. 1989 Oct;98(2):662-8. doi: 10.1111/j.1476-5381.1989.tb12641.x.
Abstract
- Cromakalim reduced intraluminal pressure in the guinea-pig isolated, innervated trachea. 2. Preganglionic stimulation of the cervical vagus nerve elicited a frequency-dependent increase in intraluminal pressure. Cromakalim attenuated responses to vagal stimulation in a concentration-dependent manner at all frequencies tested. 3. Field stimulation caused a frequency-dependent increase in intraluminal pressure mediated by muscarinic cholinoceptors. Cromakalim did not affect the amplitude of responses at any frequency of stimulation, even at high concentrations. 4. Acetylcholine, added to the Krebs solution bathing the adventitial surface of the trachea, evoked a concentration-dependent increase in intraluminal pressure. The concentration-effect curve for acetylcholine was unaltered in the presence of cromakalim. 5. It is concluded that cromakalim modulates cholinergic neuroeffector transmission in the trachea chiefly by a prejunctional mechanism. However, cromakalim probably does not interfere with acetylcholine release from postganglionic cholinergic neurones.
摘要
- 克罗卡林降低了豚鼠离体、有神经支配气管的腔内压力。2. 颈迷走神经节前刺激引起腔内压力频率依赖性增加。在所有测试频率下，克罗卡林以浓度依赖性方式减弱对迷走神经刺激的反应。3. 场刺激引起由毒蕈碱型胆碱能受体介导的腔内压力频率依赖性增加。即使在高浓度下，克罗卡林在任何刺激频率下都不影响反应幅度。4. 添加到浴于气管外膜表面的 Krebs 溶液中的乙酰胆碱引起腔内压力浓度依赖性增加。在存在克罗卡林的情况下，乙酰胆碱的浓度-效应曲线未改变。5. 得出的结论是，克罗卡林主要通过节前机制调节气管中的胆碱能神经效应器传递。然而，克罗卡林可能不会干扰节后胆碱能神经元释放乙酰胆碱。
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