Okamoto Yuko, Kosaka Hirotaka, Kitada Ryo, Seki Ayumi, Tanabe Hiroki C, Hayashi Masamichi J, Kochiyama Takanori, Saito Daisuke N, Yanaka Hisakazu T, Munesue Toshio, Ishitobi Makoto, Omori Masao, Wada Yuji, Okazawa Hidehiko, Koeda Tatsuya, Sadato Norihiro
Research Center for Child Mental Development, University of Fukui, Japan; Division of Developmental Higher Brain Functions, Department of Child Development, United Graduate School of Child Development, University of Fukui, Japan.
Research Center for Child Mental Development, University of Fukui, Japan; Division of Developmental Higher Brain Functions, Department of Child Development, United Graduate School of Child Development, University of Fukui, Japan; Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Japan.
Neurosci Res. 2017 Jun;119:38-52. doi: 10.1016/j.neures.2017.02.001. Epub 2017 Feb 11.
Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD.
患有自闭症谱系障碍（ASD）的个体在识别身体和面部方面存在困难，这种困难在儿童中比在成人中更为明显。如果这些困难源于外侧枕叶体区（EBA）和梭状回面孔区（FFA）的功能障碍，那么这些区域的激活在儿童中可能比在成人中更不典型。我们对患有ASD的儿童和成人以及年龄匹配的发育正常（TD）个体在观察面部、身体、汽车和场景时进行了功能磁共振成像。为了研究各个方面，我们进行了个体感兴趣区域（ROI）分析以及传统的随机效应组分析。在个体ROI分析中，我们检查了在四种物体类别中表现出类别敏感反应的参与者比例、区域大小、位置和激活模式。患有ASD的成人在EBA和FFA的激活方面没有异常，而患有ASD的儿童在这些区域表现出异常激活。具体而言，与TD儿童相比，患有ASD的儿童中表现出FFA面部敏感激活的比例较小。此外，患有ASD的儿童的EBA大小比TD儿童小。我们的结果显示，患有ASD的儿童在FFA和EBA中均存在异常，但患有ASD的成人则没有。
