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颗粒蛋白前体通过诱导调节性T淋巴细胞的形成来抑制人T淋巴细胞增殖。

Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes.

作者信息

Kwack Kyu Hwan, Lee Hyeon-Woo

机构信息

Institute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

出版信息

Mediators Inflamm. 2017;2017:7682083. doi: 10.1155/2017/7682083. Epub 2017 Jan 17.

DOI:10.1155/2017/7682083
PMID:28194047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5282443/
Abstract

We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF- inhibitor or a Treg inhibitor. PGRN induced TGF- secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-.

摘要

我们研究了颗粒蛋白前体（PGRN）对人T细胞增殖的影响及其潜在机制。我们发现PGRN抑制PHA诱导的T淋巴细胞增殖。当T淋巴细胞被PHA激活时，PGRN可增加诱导性调节性T细胞（iTregs）的数量，但在无PHA的情况下则不会。TGF-β抑制剂或调节性T细胞抑制剂可完全逆转PGRN介导的T淋巴细胞增殖抑制以及iTregs的诱导。在有PHA存在的情况下，PGRN可诱导TGF-β分泌，而在无PHA时则不会。我们的研究结果表明，PGRN通过增强活化T淋巴细胞响应TGF-β形成iTregs来抑制T淋巴细胞增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/8d159434c4a1/MI2017-7682083.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/8cd87d2cc847/MI2017-7682083.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/fddecb98846e/MI2017-7682083.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/c889828eafcb/MI2017-7682083.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/f52c1e90013f/MI2017-7682083.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/8d159434c4a1/MI2017-7682083.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/8cd87d2cc847/MI2017-7682083.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/fddecb98846e/MI2017-7682083.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/c889828eafcb/MI2017-7682083.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/f52c1e90013f/MI2017-7682083.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5a9/5282443/8d159434c4a1/MI2017-7682083.005.jpg

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