外显子组研究范式：理解人类健康和疾病的环境基础的机会。
The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease.
机构信息
Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA.
Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St., Boston, MA, 02115, USA.
出版信息
Curr Environ Health Rep. 2017 Mar;4(1):89-98. doi: 10.1007/s40572-017-0126-3.
PURPOSE OF REVIEW
This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan.
RECENT FINDINGS
The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts. Despite the notable challenges underlying the exposome paradigm, analytic techniques are being developed to handle its untargeted approach and correlated and multi-level or hierarchical data structures such initiatives generate, while considering multiple comparisons. The relatively short intervals for critical and sensitive windows of human reproduction and development seem well suited for exposome research and may revolutionize our understanding of later onset diseases. Early initiatives suggest that the exposome paradigm is feasible, but its utility remains to be established with applications to population human health research.
目的综述
本文概述了外显子组研究范例，特别应用于理解人类生殖和发育及其对整个生命周期健康的影响。
最新发现
外显子组研究范例引发了关于其确定环境暴露对人类健康影响的可行性和实用性的大量讨论。早期的倡议正在进行中，包括较小的原理验证研究和更大的协同努力。尽管外显子范例存在显著的挑战，但分析技术正在被开发出来，以处理其非靶向方法以及相关的多层次或分层数据结构，同时考虑到多次比较。人类生殖和发育的关键和敏感窗口期相对较短，非常适合外显子组研究，可能会彻底改变我们对后期发病疾病的理解。早期的倡议表明，外显子组范例是可行的，但仍需要通过应用于人群健康研究来确定其效用。
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