创伤后脾组织化生在趋化因子受体 CXCR4 靶向 PET/CT 中的可视化。
Visualization of Posttraumatic Splenosis on Chemokine Receptor CXCR4-Targeted PET/CT.
机构信息
From the *Department of Nuclear Medicine, Hannover Medical School, Hannover; †Radiopharmaceutical Chemistry, Technical University Munich, Garching; and ‡Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
出版信息
Clin Nucl Med. 2017 Jun;42(6):e317-e318. doi: 10.1097/RLU.0000000000001590.
The C-X-C motif chemokine receptor 4 (CXCR4) is expressed by a variety of inflammatory and malignant cells. We report the case of a 54-year-old woman with recurrent urinary tract infection who underwent a Ga-pentixafor PET/CT for detection of occult infectious foci. As a secondary finding, multiple CXCR4 abdominal lesions could be seen, consistent with the diagnosis of long-known posttraumatic splenosis. It is important to be aware that CXCR4-directed imaging may identify splenic tissue based on the presence of inflammatory cells and that both benign and malignant cells may show CXCR4 expression to avoid misinterpretation.
C-X-C 基序趋化因子受体 4（CXCR4）表达于多种炎症细胞和恶性细胞。我们报告了一例 54 岁女性，因反复发作的尿路感染行 Ga- pentixafor PET/CT 检查以发现隐匿性感染灶。偶然发现，腹部存在多个 CXCR4 阳性病变，符合人们熟知的创伤后脾组织异位的诊断。重要的是，要知道 CXCR4 靶向成像可能会根据炎症细胞的存在来识别脾脏组织，而且良性和恶性细胞都可能表现出 CXCR4 表达，以避免误诊。
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