Irokawa Daisuke, Okubo Nobuki, Nikaido Masahiko, Shimizu Hiroyasu, Konobu Hiroyuki, Matsui Tokuo, Fujita Takahisa, Goto Hiroaki, Takeuchi Takahiro, Ishii Yoshihito, Saito Atsushi
Int J Periodontics Restorative Dent. 2017 May/June;37(3):393–401. doi: 10.11607/prd.2888. Epub 2017 Feb 14.
This multicenter prospective case series study aimed to evaluate the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) in the treatment of intrabony defects. A total of 36 nonsmoking patients with chronic periodontitis were recruited in five centers in Japan. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for debridement using a papilla preservation technique. Defects were filled with DBBM and covered with CB. Clinical evidence after 6 months supported the effectiveness of the combination therapy in the treatment of intrabony defects.
这项多中心前瞻性病例系列研究旨在评估使用脱蛋白牛骨矿物质（DBBM）联合胶原屏障（CB）进行牙周再生治疗骨内缺损的效果。在日本的五个中心共招募了36例非吸烟的慢性牙周炎患者。所有患者至少有一个≥3mm的骨内缺损。手术步骤包括采用乳头保留技术进行清创。缺损处用DBBM填充并用CB覆盖。6个月后的临床证据支持了联合治疗骨内缺损的有效性。
