Demicheli R, Foroni R, Ingrosso A, Pratesi G, Soranzo C, Tortoreto M
Division of Radiotherapy and Oncology ULSS 28, Legnago, Italy.
Cancer Res. 1989 Dec 1;49(23):6543-6.
The data of nine monolayer cultures, 48 multicellular spheroids, and 19 s.c. xenografts of LoVo cells were fitted, on an individual basis, by exponential and Gompertzian equations, respectively. The mean growth parameters alpha 0 (initial growth rate) and beta (retardation factor) of the three experimental systems presented a strong linear correlation alpha 0 = 6.88 beta + 0.56, r = 0.9843. This implies that, at the particular tumor size of 155 microns in diameter (mean +/- SD = 50-310 microns), the tumor growths described by Gompertzian curves (from spheroids as well as from s.c. xenografts) have the same growth rate as monolayer cultures. This occurrence strongly supports an exponential-Gompertzian growth model, where an exponential monolayer-like phase changes to a Gompertzian growth, controlled by environmental conditions, when the tumor size has reached a critical value.
分别对9个单层培养物、48个多细胞球体和19个LoVo细胞皮下异种移植的数据进行个体拟合，分别采用指数方程和冈珀茨方程。三个实验系统的平均生长参数α0（初始生长速率）和β（阻滞因子）呈现出强烈的线性相关性α0 = 6.88β + 0.56，r = 0.9843。这意味着，在直径为155微米的特定肿瘤大小（平均±标准差 = 50 - 310微米）时，由冈珀茨曲线描述的肿瘤生长（来自球体以及皮下异种移植）与单层培养物具有相同的生长速率。这种情况有力地支持了指数 - 冈珀茨生长模型，即当肿瘤大小达到临界值时，类似指数的单层样阶段会转变为由环境条件控制的冈珀茨生长。
