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TDP-43 overexpression impairs presynaptic integrity.

作者信息

Heyburn Lanier, Moussa Charbel E-H

机构信息

Department of Neurology, Laboratory for Dementia and Parkinsonism, Translational Neurotherapeutics Program, Georgetown University Medical Center, Washington D.C., USA.

出版信息

Neural Regen Res. 2016 Dec;11(12):1910-1911. doi: 10.4103/1673-5374.195272.

DOI:10.4103/1673-5374.195272
PMID:28197178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5270420/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/5270420/47cff7a984bc/NRR-11-1910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/5270420/47cff7a984bc/NRR-11-1910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4717/5270420/47cff7a984bc/NRR-11-1910-g001.jpg

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2
A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.一种新型的TDP - 43蛋白病果蝇模型:N端序列与Q/N结构域结合导致蛋白质功能丧失和运动缺陷。
Dis Model Mech. 2016 Jun 1;9(6):659-69. doi: 10.1242/dmm.023382. Epub 2016 Apr 21.
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Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.星形胶质细胞源性血小板反应蛋白-1的合成与释放缺陷介导神经元TDP-43蛋白病,导致与慢性创伤性脑病相关的神经元完整性缺陷:体外研究
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Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells.热休克因子1的过表达通过诱导培养细胞中诱导型热休克蛋白70来维持TAR DNA结合蛋白43的溶解性。
J Neurosci Res. 2016 Jul;94(7):671-82. doi: 10.1002/jnr.23725. Epub 2016 Mar 20.
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Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.必需伴侣蛋白Sis1的过表达可降低TDP-43对毒性和蛋白水解的影响。
PLoS Genet. 2017 May 22;13(5):e1006805. doi: 10.1371/journal.pgen.1006805. eCollection 2017 May.
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Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems.静息态下行为变异型额颞叶痴呆的改变与单胺和 GABA 神经递质系统的分布有关。
Elife. 2024 Jan 15;13:e86085. doi: 10.7554/eLife.86085.
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Synaptic expression of TAR-DNA-binding protein 43 in the mouse spinal cord determined using super-resolution microscopy.

本文引用的文献

1
Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis.酪氨酸激酶抑制可逆转TDP - 43对突触蛋白表达、星形胶质细胞功能及氨基酸稳态失衡的影响。
J Neurochem. 2016 Nov;139(4):610-623. doi: 10.1111/jnc.13763. Epub 2016 Sep 27.
2
Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.帕金介导的细胞核和可溶性TDP-43的减少可逆转有症状小鼠的行为衰退。
Hum Mol Genet. 2014 Sep 15;23(18):4960-9. doi: 10.1093/hmg/ddu211. Epub 2014 May 8.
3
Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis.
利用超分辨率显微镜测定小鼠脊髓中TAR-DNA结合蛋白43的突触表达。
Front Mol Neurosci. 2023 Aug 21;16:1027898. doi: 10.3389/fnmol.2023.1027898. eCollection 2023.
4
Trends in Understanding the Pathological Roles of TDP-43 and FUS Proteins.TDP-43 和 FUS 蛋白的病理作用的研究进展。
Adv Exp Med Biol. 2021;1281:243-267. doi: 10.1007/978-3-030-51140-1_15.
5
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.TDP-43 通过胰岛中 CaV1.2 介导的胞吐作用调节早期胰岛素分泌。
J Clin Invest. 2019 Jul 29;129(9):3578-3593. doi: 10.1172/JCI124481.
6
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.肌萎缩侧索硬化症中TDP - 43错误折叠及病理变化的分子机制
Front Mol Neurosci. 2019 Feb 14;12:25. doi: 10.3389/fnmol.2019.00025. eCollection 2019.
Parkin 逆转 TDP-43 诱导的细胞死亡和氨基酸稳态失衡。
J Neurochem. 2014 Apr;129(2):350-61. doi: 10.1111/jnc.12630. Epub 2013 Dec 19.
4
Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse.突触活动调节mRNA沉默位点,以在突触处对局部蛋白质合成进行微调。
Commun Integr Biol. 2012 Jul 1;5(4):388-92. doi: 10.4161/cib.20257.
5
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.长 pre-mRNA 耗竭和 RNA 错剪接导致 TDP-43 缺失引起神经元易损性。
Nat Neurosci. 2011 Apr;14(4):459-68. doi: 10.1038/nn.2779. Epub 2011 Feb 27.
6
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor.TDP-43是额颞叶痴呆合并泛素阳性包涵体(FTLD-U)的标志性蛋白,是一种神经元活动反应因子。
J Neurochem. 2008 May;105(3):797-806. doi: 10.1111/j.1471-4159.2007.05190.x. Epub 2007 Dec 15.
7
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.额颞叶痴呆和肌萎缩侧索硬化症中泛素化的TDP-43
Science. 2006 Oct 6;314(5796):130-3. doi: 10.1126/science.1134108.