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Topoisomerase II as a target of anticancer drug action in mammalian cells.

作者信息

Kohn K W, Pommier Y, Kerrigan D, Markovits J, Covey J M

出版信息

NCI Monogr. 1987(4):61-71.

PMID:2819733
Abstract
摘要

相似文献

1
Topoisomerase II as a target of anticancer drug action in mammalian cells.拓扑异构酶II作为哺乳动物细胞中抗癌药物作用的靶点。
NCI Monogr. 1987(4):61-71.
2
Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.E2F-1/DP-1转录因子复合物过表达后拓扑异构酶I和II抗癌药物的差异细胞毒性途径
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Covalent attachment of ethidium to DNA results in enhanced topoisomerase II-mediated DNA cleavage.溴化乙锭与DNA的共价连接导致拓扑异构酶II介导的DNA切割增强。
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A cisplatin-resistant murine leukemia cell line exhibits increased topoisomerase II activity.一种耐顺铂的小鼠白血病细胞系表现出拓扑异构酶II活性增加。
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Biological properties of 4-methyl-2,7-diamino-5,10-diphenyl-4,9-diazapyrenium hydrogensulfate (ADAP).4-甲基-2,7-二氨基-5,10-二苯基-4,9-二氮杂芘硫酸氢盐（ADAP）的生物学特性
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A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent.
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Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity, and physico-chemical properties of 2-aza- and 2-aza-oxide-anthracenedione derivatives.2-氮杂以及2-氮杂氧化物-蒽二酮衍生物的拓扑异构酶II DNA切割刺激作用、DNA结合活性、细胞毒性及物理化学性质
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Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.细胞核拓扑异构酶II的水平与哺乳动物细胞对嵌入剂和表鬼臼毒素的敏感性相关。
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Topoisomerase II poisoning and antineoplastic action by DNA-nonbinding diacetyl and dicarboxaldoxime derivatives of ferrocene.二乙酰基和二羧醛肟二茂铁衍生物对拓扑异构酶II的中毒作用及抗肿瘤作用：DNA非结合机制
Arch Biochem Biophys. 2000 Apr 1;376(1):229-35. doi: 10.1006/abbi.1999.1692.

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Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy.铂类化疗后卵巢肿瘤上皮细胞和基质细胞中拓扑异构酶IIα表达模式的改变。
Neoplasia. 2006 Jan;8(1):38-45. doi: 10.1593/neo.05580.
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Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice.
Invest New Drugs. 1993 Nov;11(4):263-77. doi: 10.1007/BF00874425.
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bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy.
Br J Cancer. 1994 Sep;70(3):421-6. doi: 10.1038/bjc.1994.321.
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Alteration of topoisomerase II action is a possible molecular mechanism of HL-60 cell differentiation.拓扑异构酶II作用的改变是HL - 60细胞分化的一种可能分子机制。
Environ Health Perspect. 1990 Aug;88:183-5. doi: 10.1289/ehp.9088183.
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Nucleoside salvage and resistance to antimetabolite anticancer agents.核苷补救合成与抗代谢物抗癌药物耐药性
Br J Cancer. 1991 Sep;64(3):428-36. doi: 10.1038/bjc.1991.327.
6
Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative.椭圆玫瑰树碱衍生物刺激下哺乳动物拓扑异构酶II介导的DNA切割的序列要求
Nucleic Acids Res. 1991 Jun 11;19(11):2861-8. doi: 10.1093/nar/19.11.2861.