对多发性硬化症中类固醇试验的批判。
A critique of steroid trials in multiple sclerosis.
作者信息
Perkin G D
出版信息
Neuroepidemiology. 1987;6(1-2):40-5. doi: 10.1159/000110099.
PMID:2819752
Abstract
A review has been performed of the trials of steroids in MS published between 1958 and 1970. None of the trials concerned with the long-term treatment of the disease, whether with ACTH or oral steroids, revealed any benefit. Some advantage of steroids over placebo in accelerating the recovery of acute exacerbations can be claimed, though in no study has the gain been substantial.
摘要
对1958年至1970年间发表的关于类固醇治疗多发性硬化症的试验进行了综述。没有一项关于该疾病长期治疗的试验，无论是使用促肾上腺皮质激素还是口服类固醇，显示出任何益处。尽管在任何研究中这种益处都不显著，但可以认为类固醇在加速急性加重期恢复方面比安慰剂有一些优势。
Zotero 插件