Bourin M, Ortega A, Larousse C
Neuropsychobiology. 1987;17(1-2):35-40. doi: 10.1159/000118338.
A comparison was made between the effects of maprotiline, the sole action of which is to inhibit the reuptake of noradrenaline, of salbutamol and of viloxazine on hypothermia induced by reserpine, oxotremorine or apomorphine. The dose/effect curves in the three tests showed a similarity in profile between viloxazine and salbutamol, whereas no resemblance was evident between these two drugs and maprotiline. These facts suggest that viloxazine which has a weak effect on noradrenaline reuptake acts probably as antidepressant by betamimetic activity.
对麦普替林、沙丁胺醇和维洛沙嗪分别进行了研究，比较它们对利血平、氧化震颤素或阿扑吗啡所致体温过低的影响。麦普替林的唯一作用是抑制去甲肾上腺素再摄取，在三项试验中，维洛沙嗪和沙丁胺醇的剂量-效应曲线在外形上具有相似性，而这两种药物与麦普替林之间则无明显相似之处。这些事实表明，对去甲肾上腺素再摄取作用较弱的维洛沙嗪可能通过β-拟交感活性发挥抗抑郁作用。
