Smyth J F, Fowlie S M, Gregor A, Crompton G K, Busuttil A, Leonard R C, Grant I W
Q J Med. 1986 Oct;61(234):969-76.
Between 1971 and 1978, 140 cases of small cell anaplastic carcinoma of the bronchus were registered by a group of chest physicians in north Edinburgh. Sixty-five of these patients received specific treatment either with radiotherapy or cyclophosphamide and 75 patients were given treatment for symptoms only. Between 1979 and 1981 83 patients referred to the same physicians and pathologists were treated with combination chemotherapy (methotrexate, cyclophosphamide and CCNU) for 12 weeks. Overall median survival in the 1971 to 1978 group was two months with the actively-treated patients surviving for five months vs. less than one month for treatment of symptoms only. For the 83 patients treated with combination chemotherapy, median survival was nine months with 33 per cent alive at one year and 13 per cent at two years. Positive factors associated with prolonged survival included performance status at presentation and response to chemotherapy. This study demonstrates that the prognosis for the majority of patients with small cell carcinoma of the bronchus has improved significantly with the introduction of combination chemotherapy.
1971年至1978年间，爱丁堡北部的一组胸科医生登记了140例支气管小细胞间变性癌病例。其中65例患者接受了放疗或环磷酰胺的特异性治疗，75例患者仅接受了对症治疗。1979年至1981年间，83例转诊至同一批医生和病理学家处的患者接受了为期12周的联合化疗（甲氨蝶呤、环磷酰胺和洛莫司汀）。1971年至1978年组的总体中位生存期为两个月，接受积极治疗的患者存活了五个月，而仅接受对症治疗的患者存活时间不到一个月。对于接受联合化疗的83例患者，中位生存期为九个月，一年时33%的患者存活，两年时13%的患者存活。与生存期延长相关的积极因素包括就诊时的身体状况和对化疗的反应。这项研究表明，随着联合化疗的引入，大多数支气管小细胞癌患者的预后有了显著改善。
