Pomare E W, Hillman L C, Peters S, Fisher A
Scand J Gastroenterol Suppl. 1987;129:181-4. doi: 10.3109/00365528709095881.
There are few studies in man examining the in vivo effects of dietary fibre on bile acid metabolism but divergent results have been recorded depending on the amount and type of fibre eaten. Studies in which the fibre components pectin, cellulose, and lignin were fed to normal volunteers for four weeks have been reported. The highly fermentable component pectin is associated with increased secondary bile acid formation in contrast to the partially fermentable component cellulose in which the opposite occurs. Lignin has no effect on bile acid metabolism. No component significantly alters biliary lipids. Since ordinary diets contain a mixture of different fibres the net effect will depend on the relative amounts of each. Significant changes in bile acid metabolism and biliary lipids in the longer term (greater than 4 weeks) however, are not precluded by the results of these short term studies.
关于膳食纤维对人体胆汁酸代谢的体内影响的研究较少，但根据所摄入纤维的量和类型不同，已有不同的研究结果记录。有报道称，将果胶、纤维素和木质素等纤维成分喂给正常志愿者四周的研究。与部分可发酵的纤维素成分相反，高度可发酵的果胶成分与次级胆汁酸形成增加有关，而纤维素则出现相反情况。木质素对胆汁酸代谢没有影响。没有哪种成分会显著改变胆汁脂质。由于普通饮食包含不同纤维的混合物，其净效应将取决于每种纤维的相对含量。然而，这些短期研究的结果并不排除从长期来看（超过4周）胆汁酸代谢和胆汁脂质会发生显著变化。
