Morita T, Wada I, Suzuki T, Tsuchida S
Tohoku J Exp Med. 1987 Jun;152(2):111-8. doi: 10.1620/tjem.152.111.
Experiments were carried out in the dog by the use of experimental procedure which permits to assess independently changes in uretheral peristaltic frequency, bolus volume and intraluminal pressure and flow volume in order to characterize alpha-adrenoceptor subtypes involved in regulation of ureteral urine transport. Norepinephrine caused an increase in ureteral peristaltic frequency, an elevation in intraureteral baseline and contractile pressure and a decrease in bolus volume, with a resultant decrease in the rate of fluid transport. Phenylephrine (alpha 1-agonist) and clonidine (alpha 2-agonist) caused the effects similar to those of norepinephrine on peristaltic frequency, intraureteral baseline and contractile pressure, and bolus volume. Phentolamine (non-selective alpha-antagonist) and prazosin (alpha 1-antagonist) caused a decrease in ureteral peristaltic frequency, and a fall in intraureteral baseline and contractile pressure, and yohimbine (alpha 2-antagonist) abolished peristalsis and bolus formation. These changes were accompanied by an increase in the rate of fluid transport. These data suggest that the ureteral urine transport is controlled by activation of both alpha 1- and alpha 2-adrenoceptors through regulation of peristaltic frequency and bolus volume.
通过使用允许独立评估输尿管蠕动频率、团块体积以及管腔内压力和流量变化的实验程序，在狗身上进行了实验，以表征参与输尿管尿液输送调节的α-肾上腺素能受体亚型。去甲肾上腺素导致输尿管蠕动频率增加、输尿管内基线和收缩压升高以及团块体积减小，从而导致液体输送速率降低。苯肾上腺素（α1-激动剂）和可乐定（α2-激动剂）对蠕动频率、输尿管内基线和收缩压以及团块体积产生了与去甲肾上腺素类似的作用。酚妥拉明（非选择性α-拮抗剂）和哌唑嗪（α1-拮抗剂）导致输尿管蠕动频率降低，输尿管内基线和收缩压下降，而育亨宾（α2-拮抗剂）则消除了蠕动和团块形成。这些变化伴随着液体输送速率的增加。这些数据表明，输尿管尿液输送是通过调节蠕动频率和团块体积，由α1-和α2-肾上腺素能受体的激活来控制的。
