Sagheer Safoorah, McRae Simon
Haematology Division, SA Pathology, Adelaide, South Australia, Australia.
Haematology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Intern Med J. 2017 Feb;47(2):225-227. doi: 10.1111/imj.13343.
Rivaroxaban is an oral direct Xa inhibitor that can lead to prolongation of prothrombin time and activated partial thromboplastin time. However, these basic coagulation tests are not specific for the anticoagulant effect of rivaroxaban and other confounding factors should be considered while interpreting the test results. We report a case of a patient on rivaroxaban, where underlying factor VII deficiency led to confusion in the interpretation of prothrombin time results and delayed her surgery.
利伐沙班是一种口服直接Xa因子抑制剂，可导致凝血酶原时间和活化部分凝血活酶时间延长。然而，这些基本凝血试验并非利伐沙班抗凝作用所特有，在解释试验结果时应考虑其他混杂因素。我们报告一例服用利伐沙班的患者，其潜在的因子VII缺乏导致凝血酶原时间结果解读混乱，并延误了手术。
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