Colle Romain, Segawa Tomoyuki, Chupin Marie, Tran Dong Minh Ngoc Thien Kim, Hardy Patrick, Falissard Bruno, Colliot Olivier, Ducreux Denis, Corruble Emmanuelle
INSERM UMRS 1178, Team "Depression and Antidepressants", 94275, Le Kremlin Bicêtre, France.
Faculté de Médecine Paris Sud, Univ. Paris-Sud, 94275, Le Kremlin Bicêtre, France.
BMC Psychiatry. 2017 Feb 15;17(1):71. doi: 10.1186/s12888-017-1233-2.
Three studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the association of ELA and hippocampal volumes in depressed patients, while focusing specifically on sex and controlling for several relevant socio-demographic and clinical variables.
Sixty-three depressed in-patients treated in a psychiatric setting, with a current Major Depressive Episode (MDE) and a Major Depressive Disorder (MDD) were included and assessed for ELA. Hippocampal volumes were measured with brain magnetic resonance imaging (MRI) and automatic segmentation. They were compared between patients with (n = 28) or without (n = 35) ELA. After bivariate analyses, multivariate regression analyses tested the interaction of sex and ELA on hippocampal volume and were adjusted for several potential confounding variables. The subgroups of men (n = 26) and women (n = 37) were assessed separately.
Patients with ELA had a smaller hippocampus than those without ELA (4.65 (±1.11) cm versus 5.25 (±1.01) cm), bivariate: p = 0.03, multivariate: HR = 0.40, 95%CI [0.23;0.71], p = 0.002), independently from other factors. This association was found in men (4.43 (±1.22) versus 5.67 (±0.77) cm), bivariate: p = 0.006, multivariate HR = 0.23, 95%CI [0.06;0.82], p = 0.03) but not in women.
ELA is associated with a smaller hippocampus in male but not female depressed in-patients. The reasons for this association should be investigated in further studies.
三项研究评估了早年生活逆境（ELA）与抑郁症患者海马体体积之间的关联，其中一项研究结果为阴性，另外两项研究未对多个潜在混杂变量进行控制。由于ELA与海马体体积的关联在男性和女性健康志愿者中有所不同，我们调查了抑郁症患者中ELA与海马体体积的关联，特别关注性别，并控制了多个相关的社会人口学和临床变量。
纳入63名在精神科接受治疗的抑郁症住院患者，这些患者目前患有重度抑郁发作（MDE）和重度抑郁症（MDD），并对其ELA进行评估。采用脑磁共振成像（MRI）和自动分割技术测量海马体体积。对有（n = 28）或无（n = 35）ELA的患者进行比较。在双变量分析之后，多变量回归分析测试了性别和ELA对海马体体积的相互作用，并对多个潜在混杂变量进行了调整。分别对男性（n = 26）和女性（n = 37）亚组进行评估。
有ELA的患者海马体比无ELA的患者小（4.65（±1.11）cm对5.25（±1.01）cm），双变量分析：p = 0.03，多变量分析：HR = 0.40，95%CI [0.23;0.71]，p = 0.002），独立于其他因素。这种关联在男性中存在（4.43（±1.22）对5.67（±0.77）cm），双变量分析：p = 0.006，多变量HR = 0.23，95%CI [0.06;0.82]，p = 0.03），但在女性中不存在。
在男性抑郁症住院患者中，ELA与较小的海马体有关，而在女性中则不然。这种关联的原因应在进一步研究中进行调查。
