Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universitaet Dresden, Dresden, Germany.
Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Affect Disord. 2019 Jun 1;252:152-159. doi: 10.1016/j.jad.2019.04.054. Epub 2019 Apr 9.
Smaller hippocampus volume represents a consistent finding in major depression (MDD). Hippocampal neuroplasticity due to chronic stress might have differential effect on hippocampal subfields. We investigated the effects of the rs1360780 polymorphism of the hypothalamic-pituitary-axis related gene FKBP5 in combination with early life stress (ELA) on the structure of hippocampal subfields in MDD.
We assessed the hippocampal subfields volumes in 85/67 MDD/healthy controls. We investigated the effects of diagnosis, FKBP5 allelic status and their interaction as predictors of hippocampal subfield volumes as well as the effect of ELA and its interaction with FKBP5.
MDD patients had smaller hippocampal volumes, in particular within the cornu ammonis (CA) and dentate gyrus (DG) regions. Patients exposed to ELA had larger hippocampi, in particular within the CA and DG. Among the patients exposed to ELA, the T allele carriers displayed lower volumes within the hippocampus-amygdala-transition-area (HATA) as those subjects homozygous for the C allele.
We pooled the subjects from 2 centers in order to increase the sample size. We did not include the cumulative lifetime exposure to medication.
Hippocampal volume reductions in MDD were present particularly in the CA and DG. MDD with ELA display differential volume changes compared to MDD without ELA. The significant interaction between ELA and the rs1360780 polymorphism in HATA suggests a role of FKBP5 in the pathophysiology of structural alterations in depression.
较小的海马体体积是重度抑郁症（MDD）的一个一致发现。慢性应激引起的海马神经可塑性可能对海马亚区产生不同的影响。我们研究了下丘脑-垂体轴相关基因 FKBP5 的 rs1360780 多态性与早期生活应激（ELA）相结合对 MDD 中海马亚区结构的影响。
我们评估了 85/67 名 MDD/健康对照者的海马亚区体积。我们研究了诊断、FKBP5 等位基因状态及其与海马亚区体积的相互作用作为预测因子的影响，以及 ELA 及其与 FKBP5 的相互作用的影响。
MDD 患者的海马体积较小，特别是在角回（CA）和齿状回（DG）区域。暴露于 ELA 的患者海马体积较大，特别是在 CA 和 DG 区域。在暴露于 ELA 的患者中，T 等位基因携带者的海马-杏仁核-过渡区（HATA）体积低于 C 等位基因纯合子的受试者。
我们为了增加样本量，将来自 2 个中心的受试者进行了合并。我们没有包括累积的终生用药暴露。
MDD 患者的海马体积减少主要发生在 CA 和 DG 区域。与无 ELA 的 MDD 相比，有 ELA 的 MDD 显示出不同的体积变化。HATA 中 ELA 和 rs1360780 多态性之间的显著相互作用表明 FKBP5 在抑郁症结构改变的病理生理学中发挥作用。
