Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kidney Int. 2017 Mar;91(3):529-531. doi: 10.1016/j.kint.2016.11.019.
Renin-angiotensin system inhibition with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has been shown to be effective in reducing progression of renal and cardiovascular disease. However, these medications are often associated with an initial reduction of estimated glomerular filtration rate, which is thought to be functional but may be of clinical significance. Newer insights from secondary analyses of large clinical trials may provide important clinical perspective.
肾素-血管紧张素系统抑制作用，无论是血管紧张素转换酶抑制剂还是血管紧张素受体阻滞剂，已被证明可有效减少肾脏和心血管疾病的进展。然而，这些药物通常与估算肾小球滤过率的初始降低有关，这被认为是功能性的，但可能具有临床意义。来自大型临床试验的二次分析的新见解可能提供重要的临床观点。
