Nagatomo Y, Yoshida T, Kodama K, Kambe H, Tanaka K
Am J Gastroenterol. 1987 Sep;82(9):910-1.
HLA-A, -B, -C, and -DR typing was performed in a pedigree with familial polyposis coli (FPC). Three living members with FPC and one member without obvious FPC had the same HLA haplotype; A24(9)-B51-X-DRw8 (X indicates undetected HLA-C locus). It was genetically deduced that a deceased member with FPC also had this haplotype. No other members had this haplotype. No association was found between FPC and other HLA haplotypes. Thus an association between the specific HLA haplotype and FPC was suspected in this family.
对一个患有家族性结肠息肉病（FPC）的家系进行了HLA - A、- B、- C和 - DR分型。三名患有FPC的在世成员和一名无明显FPC的成员具有相同的HLA单倍型；A24(9)-B51-X-DRw8（X表示未检测到的HLA - C位点）。经遗传学推断，一名已故的患有FPC的成员也具有这种单倍型。没有其他成员具有这种单倍型。未发现FPC与其他HLA单倍型之间存在关联。因此，怀疑在这个家族中特定的HLA单倍型与FPC之间存在关联。
