Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of Neurology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
EBioMedicine. 2017 Mar;17:206-215. doi: 10.1016/j.ebiom.2017.02.006. Epub 2017 Feb 8.
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation. Thus, our study supports a "Lamarckian"-like mechanism of pathogenesis and the crucial role of epigenetic factors in neurological conditions.
环境暴露在个体发育早期对其日后患病易感性起着重要作用。在这里，我们证明了通过使幼鼠暴露于热环境中诱发长时间热性惊厥，不仅增强了这些热疗处理大鼠的惊厥易感性，而且增强了其后代的惊厥易感性，即使这些后代从未经历过热性惊厥。这种跨代传递具有强度依赖性，主要来自母亲向其后代的传递。这种传递与 DNA 甲基化有关。因此，我们的研究支持了一种类似拉马克主义的发病机制和表观遗传因素在神经疾病中的关键作用。
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