Hjeresen D L, Diaz J
Biophysics/Neurobiology Group, Los Alamos National Laboratory, NM 87545.
Dev Psychobiol. 1988 Apr;21(3):261-75. doi: 10.1002/dev.420210307.
Two experiments were conducted using microwave hyperthermia (MHT) to induce seizures among limited numbers of Long-Evans rat pups. The MHT model of febrile seizures eliminates several methodological complications inherent in previous animal models of the disorder. In Experiment 1, rat pups were rendered hyperthermic with MHT or were sham-irradiated on Days 11, 13, 15 or 17 postpartum. The results indicate a statistically significant decline in seizure susceptibility with age. In Experiment 2, rats were subjected to either single or multiple hyperthermic episodes on Days 11, 13, 15, or 17 postpartum. The results indicate an increase in susceptibility to seizures attributable to prior seizure history. In both experiments, seizures were induced with increases in rectal temperature of 1 to 3 degrees C. The results parallel many clinical features of febrile seizures and argue the efficacy of the MHT model.
进行了两项实验，使用微波热疗（MHT）在有限数量的长 Evans 大鼠幼崽中诱发癫痫发作。发热性癫痫发作的 MHT 模型消除了先前该疾病动物模型中固有的几个方法学上的复杂性。在实验 1 中，在产后第 11、13、15 或 17 天，用 MHT 使大鼠幼崽体温过高或进行假照射。结果表明癫痫易感性随年龄有统计学意义的下降。在实验 2 中，在产后第 11、13、15 或 17 天，大鼠经历单次或多次体温过高发作。结果表明，由于先前的癫痫发作史，癫痫易感性增加。在两项实验中，通过将直肠温度升高 1 至 3 摄氏度来诱发癫痫发作。结果与发热性癫痫发作的许多临床特征相似，并证明了 MHT 模型的有效性。
